纯度:98% by TLC [50% ethyl acetate in hexanes; Rf = 0.17] NMR conforms
分子式:C20H14ClN3O2
分子量:363.81
溶剂:DMSO (20 mg/ml); Ethanol (20 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):CHK2 inhibitor
Function / Pharmacology:Potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the selectivity1. Also displays radioprotective activity, preventing apoptosis in human T-cells that were subjected to ionizing radiation (EC50 = 3.0 – 7.6 μM).