纯度:98% by TLC,;NMR (Conforms)
分子式:C24H25N5O
分子量:399.49
溶剂:DMSO (3 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):AMPK inhibitor
Function / Pharmacology:Potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6).2 Dorsomorphin has been shown to promote cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro.3 Induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.4