纯度:98% by TLC NMR conforms
分子式:C14H8N2O
分子量:220.23
溶剂:DMSO (22 mg/ml) Ethanol (2 mg/ml)
性状:Yellow solid
存储:RT
Activity (short version):JNK inhibitor
Function / Pharmacology:Selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50’s range from 40-90 nM). >300-fold selectivity for JNK as compared to related MAP kinases. Antiinflammatory activity. Inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable and active in vivo.