纯度:98% by TLC NMR conforms
分子式:C19H10N2O3 ? CH3COOH
分子量:314.30 ? 60.05
溶剂:DMSO (10 mg/ml)
性状:Yellow solid
存储:RT
Activity (short version):CAMKK inhibitor
Function / Pharmacology:Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively).1 Binds to the ATP-binding site.2 Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Important tool for probing distinct CaMK pathways in LTP.3 Reduces starvation-induced autophagosomal membrane formation.4 Reverses age-associated decline in bone mass.5 Stimulates osteoblast formation, inhibits osteoclast differentiation.6