纯度:98% by TLC [10% methanol in methylene chloride; Rf = 0.30]
分子式:C29H31N5O4
分子量:513.59
溶剂:DMSO (50 mg/ml) Ethanol (25 mg/ml)
性状:White solid
存储:RT
Activity (short version):Aurora B kinase inhibitor
Function / Pharmacology:ZM-447439 is a selective ATP-competitive inhibitor of Aurora kinase B1 (IC50 = 50 nM, Aur A IC50 = 1 μM, Aur C IC50 = 250 nM at physiological ATP concentrations2, Ref.1 lists Aur A IC50 = 110nM and Aur B IC50 = 113nM). It did not significantly inhibit a panel of 14 other kinases including mitotic kinases CDK1 and PLK1. It prevents chromosome alignment, spindle checkpoint function and cytokinesis.1,2