纯度:98% by TLC [ 10% methanol in methylene chloride, Rf = 0.50] NMR Conforms
分子式:C17H14N2O3
分子量:294.31
溶剂:DMSO (25 mg/ml) DMF (40 mg/ml) Ethanol (10 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):JAK-2 inhibitor
Function / Pharmacology:A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4.