纯度:>98% by TLC [10% methanol / methylene chloride, Rf = 0.40];NMR (Conforms)
分子式:C20H17FO4S
分子量:372.41
溶剂:DMSO (25 mg/ml)
性状:Yellow solid
存储:RT
Activity (short version):Modulates β-catenin-mediated effects
Function / Pharmacology:Metabolite of the cyclooxygenase inhibitor sulindac that induces apoptosis via inhibition of type 5 phosphodiesterases.1 Sulindac sulfone does not inhibit cyclooxygenase at physiological concentrations but does inhibit K-ras-dependent cyclooxygenase-2 expression in colon cancer cells.2