纯度:98% by TLC [10% Methanol in methylene chloride, Rf = 0.60] NMR Conforms
分子式:C11H12ClNO
分子量:209.67
溶剂:DMSO (25 mg/ml) Ethanol (25 mg/ml)
性状:White solid
存储:RT
Activity (short version):TRPA1 blocker
Function / Pharmacology:TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 μM.1 Blocks TRPA1 pore dilation (IC50=10.3 μM).2 An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.3-5