纯度:98% by TLC, NMR Conforms
分子式:C18H15NO3
分子量:293.32
溶剂:DMSO
性状:White solid
存储:RT
Activity (short version):NFκB inhibitor
Function / Pharmacology:Oxaprozin is a clinically useful non-steroidal anti-inflammatory drug.1 In addition to typical NSAID COX inhibition, Oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-kappaβ pathway.2 The compound is capable of inhibiting both anandamide hydrolase in neurons (IC50= 85 μmol/l), with consequent potent analgesic activity, and NF-kappaB activation in inflammatory cells (IC50 = 50 μmol/l).3