纯度:98% NMR Conforms
分子式:C20H28O2
分子量:300.44
溶剂:DMSO (8 mg/ml) Ethanol (15 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Retinoid RAR agonist
Function / Pharmacology:All?trans?Retinoic acid (ATRA; a metabolite of Vitamin A) is an endogenous ligand for the retinoic acid receptor (RAR). The binding of retinoic acid to the RAR and retinoid X (RXR) heterodimer causes conformation changes in RAR that affects the binding of other proteins that regulate the growth and differentiation of a variety of both normal and malignant cells.1 ATRA promotes differentiation of embryonic stem cells (ESCs) into a variety of cell types in vitro.2-4