纯度:98% by TLC [5% methanol in methylene chloride, Rf = 0.37] NMR Conforms
分子式:C13H13N3OS
分子量:259.33
溶剂:DMSO (20 mg/ml) Ethanol (5 mg/ml)
性状:Pale yellow solid
存储:RT
Activity (short version):Necroptosis inhibitor
Function / Pharmacology:Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2 It displays a protective effect in a mouse model of ischemic brain injury1, inhibits myocardial cell death and reduces infarct size in various mouse heart models3 and inhibits glutamate-induced oxytosis in HT-22 cells4.