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KB-R7943 mesylate
- 英文名称：KB-R7943 mesylate
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10134
- cas：182004-65-5
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10134 |
| 用途 | 科研检测 |
| 英文名称 | KB-R7943 mesylate |
| 包装规格 | 1MG |
| CAS编号 | 182004-65-5 |
| 别名 | KB-R7943 mesylate |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC [ 10% methanol in methylene chloride + 0.1% NH4OH; Rf = 0.40];NMR (Conforms)
分子式:C16H17N3O3S ? CH3SO3H
分子量:427.49
溶剂:DMSO (50 mg/ml)
性状:Tan solid
存储:RT
Activity (short version):TRPC channel blocker
Function / Pharmacology:KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50’s = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7μM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) – Ki = 5.5 μM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM) and block NMDA receptors (IC50 = 13.4 μM).4
分子式:C16H17N3O3S ? CH3SO3H
分子量:427.49
溶剂:DMSO (50 mg/ml)
性状:Tan solid
存储:RT
Activity (short version):TRPC channel blocker
Function / Pharmacology:KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50’s = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7μM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) – Ki = 5.5 μM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM) and block NMDA receptors (IC50 = 13.4 μM).4
