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KB-R7943 mesylate
- 英文名称:KB-R7943 mesylate
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10134
- cas:182004-65-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10134 |
用途 | 科研检测 |
英文名称 | KB-R7943 mesylate |
包装规格 | 1MG |
CAS编号 | 182004-65-5 |
别名 | KB-R7943 mesylate |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC [ 10% methanol in methylene chloride + 0.1% NH4OH; Rf = 0.40];NMR (Conforms)
分子式:C16H17N3O3S ? CH3SO3H
分子量:427.49
溶剂:DMSO (50 mg/ml)
性状:Tan solid
存储:RT
Activity (short version):TRPC channel blocker
Function / Pharmacology:KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50’s = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7μM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) – Ki = 5.5 μM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM) and block NMDA receptors (IC50 = 13.4 μM).4
分子式:C16H17N3O3S ? CH3SO3H
分子量:427.49
溶剂:DMSO (50 mg/ml)
性状:Tan solid
存储:RT
Activity (short version):TRPC channel blocker
Function / Pharmacology:KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50’s = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7μM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) – Ki = 5.5 μM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM) and block NMDA receptors (IC50 = 13.4 μM).4