纯度:98% by TLC, NMR Conforms,
分子式:C15H10O4
分子量:254.25
溶剂:DMSO (25 mg/ml) Ethanol (6 mg/ml)
性状:Yellow or tan solid
存储:-20°C
Activity (short version):TrkB agonist/neurotrophic
Function / Pharmacology:A selective TrkB agonist (Kd=320 nM) with potent neurotrophic activity.1,2 Significantly improves motor deficits, ameliorates brain atrophy and extends survival in the well-characterized N171-82Q Huntington’s disease mouse model.3 Post-traumatic brain injury-treatment promotes neurogenesis in the hippocampus in a mouse model.4 Improves motor performance and motor neuronal survival in an ALS mouse model.5