纯度:98% by TLC [10% ethyl acetate in hexanes; Rf = 0.38] NMR Conforms
分子式:C10H5F3N4O
分子量:254.17
溶剂:DMSO (25 mg/ml) Ethanol (25 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Mitochondrial oxidative phosphorylation inhibitor
Function / Pharmacology:An extremely potent uncoupler of mitochondrial oxidative phosphorylation (IC50 = 20 nM).1 Induces apoptosis in a variety of cell lines.2 Inhibits wild type and mutant beta-amyloid production in embryonic kidney 293 cells expressing either wild-type or “Swedish” mutant APP.3 An important tool for inhibiting mitochondrial membrane potential.2,4 Cell permeable.