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PIT-1
- 英文名称:PIT-1
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10156
- cas:53501-41-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10156 |
用途 | 科研检测 |
英文名称 | PIT-1 |
包装规格 | 1MG |
CAS编号 | 53501-41-0 |
别名 | PIT-1 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C14H10ClN3O4S
分子量:351.76
溶剂:DMSO (25 mg/ml) Ethanol (3 mg/ml)
性状:Grey solid
存储:RT
Activity (short version):PH domain antagonist
Function / Pharmacology:PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
分子式:C14H10ClN3O4S
分子量:351.76
溶剂:DMSO (25 mg/ml) Ethanol (3 mg/ml)
性状:Grey solid
存储:RT
Activity (short version):PH domain antagonist
Function / Pharmacology:PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.