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PIT-1
- 英文名称：PIT-1
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10156
- cas：53501-41-0
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10156 |
| 用途 | 科研检测 |
| 英文名称 | PIT-1 |
| 包装规格 | 1MG |
| CAS编号 | 53501-41-0 |
| 别名 | PIT-1 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C14H10ClN3O4S
分子量:351.76
溶剂:DMSO (25 mg/ml) Ethanol (3 mg/ml)
性状:Grey solid
存储:RT
Activity (short version):PH domain antagonist
Function / Pharmacology:PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
分子式:C14H10ClN3O4S
分子量:351.76
溶剂:DMSO (25 mg/ml) Ethanol (3 mg/ml)
性状:Grey solid
存储:RT
Activity (short version):PH domain antagonist
Function / Pharmacology:PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
