纯度:98% by TLC,;NMR (Conforms)
分子式:C24H37NO2
分子量:371.56
溶剂:DMSO (35 mg/ml)
性状:Colorless to yellow oil
存储:-80°C
Activity (short version):Endogenous agonist at GPR110
Function / Pharmacology:Anandamide-like lipid mediator produced from DHA in the brain. Stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons at 10-100 nM.1 Potently induces neuronal differentiation of neural stem cells.2 Promotes growth of cortical axons vial modulation of hedgehog signaling.3 Binds to and activates orphan receptor GPR110, stimulating cAMP production at low nM concentrations.4 Reduces LPS-induced TNFα production in cultured microglia cells and ameliorates LPS-induced neuroinflammation in a mouse model.5