纯度:98% by HPLC;NMR (Conforms)
分子式:C9H5N3O2
分子量:187.15
溶剂:DMSO (40 mg/ml)
性状:Pale-yellow solid
存储:-20°C
Activity (short version):Soluble guanylyl cyclase inhibitor
Function / Pharmacology:A potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2 ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1 ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5