纯度:98% by TLC, NMR Conforms
分子式:C14H16BNO
分子量:225.1
溶剂:DMSO (20 mg/ml) Ethanol (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):TRP blocker
Function / Pharmacology:An IP3 receptor antagonist (IC50=42 μM).1 Inhibits store-operated Ca2+ channels at high concentrations (50 μM) but stimulates at low concs. (<10 μM).2 Modulates TRP channels, blocking TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8, TRPP2 and at higher concentrations, activating TRPV1, TRPV2, TRPV3.3,4 Also inhibits selected GAP junction subtypes.5