纯度:98% by HPLC;NMR (Conforms)
分子式:C20H22N8O5·xH2O
分子量:683.63
溶剂:DMSO (45 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Dihydrofolate reductase inhibitor
Function / Pharmacology:A synthetic folic acid analog with immunosuppressant and cancer chemotherapeutic activity.1 Inhibits thymidylate synthetase and de novo purine synthesis.2,3 Displays beneficial effects in rheumatoid arthritis by inhibiting the production of cytokines induced by T-cell activation4 and stimulation of adenosine release5. It is the classic disease-modifying antirheumatic drug (DMARD).6