纯度:98% by HPLC;NMR (Conforms)
分子式:C9H13N3O5
分子量:243.22
溶剂:DMSO (12 mg/ml) Water (24 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):DNA synthesis and transcription disruptor
Function / Pharmacology:A nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells.1,2 It Cellular enzymes convert it to its nucleotide form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it.3,4 For the same reasons, it is also employed as an antiviral.5 It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML).6,7