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6-Thioguanine
- 英文名称:6-Thioguanine
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10197
- cas:154-42-7
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10197 |
用途 | 科研检测 |
英文名称 | 6-Thioguanine |
包装规格 | 1MG |
CAS编号 | 154-42-7 |
别名 | 6-Thioguanine |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:96% by HPLC;NMR (Conforms)
分子式:C5H5N5S
分子量:167.19
溶剂:DMF (1.5 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Anticancer agent / downregulates DNMT1
Function / Pharmacology:After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.
分子式:C5H5N5S
分子量:167.19
溶剂:DMF (1.5 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Anticancer agent / downregulates DNMT1
Function / Pharmacology:After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.