纯度:96% by HPLC;NMR (Conforms)
分子式:C5H5N5S
分子量:167.19
溶剂:DMF (1.5 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Anticancer agent / downregulates DNMT1
Function / Pharmacology:After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.