纯度:98% by HPLC,;NMR (Conforms)
分子式:C10H11F3N2O5
分子量:296.20
溶剂:DMSO (25 mg/ml) Water (14 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Thymidylate synthase inhibitor; Anti-cancer agent
Function / Pharmacology:An analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity.1,2 After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes.3 Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.4