纯度:98% by TLC, NMR conforms
分子式:C21H25N5O4S
分子量:443.53
溶剂:DMSO (10 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Nedd8 activating enzyme inhibitor
Function / Pharmacology:MLN4924 is a potent and selective NEDD8-activating enzyme (NAE) inhibitor.1 It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Suppresses the growth of human tumor xenografts in mice.2 Upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma.3 Modulates tumor microenvironment.4 Blocks the neddylation of the DNA endonuclease CtIP, which promotes HDR in Cas9- and Cpf1-mediated gene editing. Part of the CRISPY mix for increasing precise gene editing.5 Cell permeable.