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K-858
- 英文名称：K-858
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10222
- cas：72926-24-0
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10222 |
| 用途 | 科研检测 |
| 英文名称 | K-858 |
| 包装规格 | 1MG |
| CAS编号 | 72926-24-0 |
| 别名 | K-858 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC, NMR( conforms)
分子式:C13H15N3O2S
分子量:277.35
溶剂:DMSO (25 mg/ml) Ethanol (3 mg/ml)
性状:White solid
存储:RT
Activity (short version):Kinesin Eg5 inhibitor
Function / Pharmacology:Selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner1,2. It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 blocks centrosome separation, activates the spindle checkpoint and induces mitotic arrest accompanied by the formation of monopolar spindles. Displays no effect on microtubule polymerization. Selectively displays antiproliferative effects via induction of mitotic cell death in cancer cells over nontransformed cells1.
分子式:C13H15N3O2S
分子量:277.35
溶剂:DMSO (25 mg/ml) Ethanol (3 mg/ml)
性状:White solid
存储:RT
Activity (short version):Kinesin Eg5 inhibitor
Function / Pharmacology:Selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner1,2. It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 blocks centrosome separation, activates the spindle checkpoint and induces mitotic arrest accompanied by the formation of monopolar spindles. Displays no effect on microtubule polymerization. Selectively displays antiproliferative effects via induction of mitotic cell death in cancer cells over nontransformed cells1.
