纯度:98% by TLC, NMR Conforms
分子式:C13H8N4OS
分子量:268.30
溶剂:DMSO (15 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):PKR inhibitor
Function / Pharmacology:Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM)1. Inhibits ER stress-induced neuronal damage2. Reduces brain PKR activation in vivo3. Prevents apoptosis and IL-1β production in an acute excitotoxic and neuroinflammatory rat model4. Prevents β-amyloid peptide-induced inflammation in primary murine mixed co-cultures5. Cell permeable.