纯度:>98% by HPLC
分子式:C28H38N6O2
分子量:600.02
溶剂:Water (50 mg/ml) DMSO (50 mg/ml)
性状:Off-white solid
存储:RT
Activity (short version):Histone Methyl transferase inhibitor+D257
Function / Pharmacology:BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 μM) as well as GLP HMTase (IC50 = 38 μM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in vitro.1 BIX-01294 facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells.3