纯度:>95%
分子式:C38H50O6
分子量:602.80
溶剂:DMSO (25 mg/ml) Ethanol (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):HAT inhibitor
Function / Pharmacology:Garcinol is a HAT (histone acetyltransferase) inhibitor (p300 IC50=7μM and PCAF IC50=5μM) both in vitro and in vivo.1 It potentiates TRAIL-induced apoptosis of cancer cells. Garcinol, independent of the cell type, induces both of the TRAIL receptors, death receptor 4 (DR4) and DR5. Garcinol neither induces the receptors of normal cells nor sensitizes them to TRAIL.2