纯度:98% by TLC,;NMR (Conforms)
分子式:C15H16ClN3O3
分子量:321.77
溶剂:DMSO (15 mg/ml) Ethanol (55 mg/ml)
性状:Red solid
存储:-20°C
Activity (short version):Cdc25 phosphatase inhibitor
Function / Pharmacology:Potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B1. Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation2. Inhibits the growth of a variety of human tumor cell lines3. Acts via irreversible oxidation of the catalytic cysteine of CDC254.