纯度:98% by TLC;NMR (Conforms)
分子式:C18H17NO4
分子量:311.33
溶剂:DMSO (50 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):LSF inhibitor
Function / Pharmacology:Inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 ?M). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2 In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3 Blocks LSF-stimulated activation of DNA methyltransferase 1.4 Cell permeable.