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JQ1 (+/-)
- 英文名称：JQ1 (+/-)
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10264
- cas：1268524-69-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-16
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10264 |
| 用途 | 科研检测 |
| 英文名称 | JQ1 (+/-) |
| 包装规格 | 1MG |
| CAS编号 | 1268524-69-1 |
| 别名 | JQ1 (+/-) |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C23H25ClN4O2S
分子量:457.00
溶剂:DMSO (9 mg/ml) Ethanol (9 mg/ml)
性状:White solid
存储:RT
Activity (short version):Bromodomain inhibitor
Function / Pharmacology:JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers1.
分子式:C23H25ClN4O2S
分子量:457.00
溶剂:DMSO (9 mg/ml) Ethanol (9 mg/ml)
性状:White solid
存储:RT
Activity (short version):Bromodomain inhibitor
Function / Pharmacology:JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers1.
