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GSK-J1
- 英文名称：GSK-J1
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10288
- cas：1373422-53-7
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-12-08
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10288 |
| 用途 | 科研检测 |
| 英文名称 | GSK-J1 |
| 包装规格 | 1MG |
| CAS编号 | 1373422-53-7 |
| 别名 | GSK-J1 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:99% by TLC,;NMR (Conforms)
分子式:C22H23N5O2
分子量:389.46
溶剂:DMSO (20 mg/ml)
性状:Pale yellow solid
存储:RT
Activity (short version):JMJ H3K27 Demethylase inhibitor (Non-cell permeable)
Function / Pharmacology:Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
分子式:C22H23N5O2
分子量:389.46
溶剂:DMSO (20 mg/ml)
性状:Pale yellow solid
存储:RT
Activity (short version):JMJ H3K27 Demethylase inhibitor (Non-cell permeable)
Function / Pharmacology:Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
