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GSK-J4
- 英文名称：GSK-J4
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10289
- cas：1373423-53-0
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10289 |
| 用途 | 科研检测 |
| 英文名称 | GSK-J4 |
| 包装规格 | 1MG |
| CAS编号 | 1373423-53-0 |
| 别名 | GSK-J4 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:99% by TLC,;NMR (Conforms)
分子式:C24H27N5O2
分子量:417.48
溶剂:DMSO (40 mg/ml) Ethanol (40 mg/ml)
性状:Yellow waxy solid
存储:-20°C
Activity (short version):JMJ H3K27 Demethylase inhibitor (Cell Permeable)
Function / Pharmacology:Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.
分子式:C24H27N5O2
分子量:417.48
溶剂:DMSO (40 mg/ml) Ethanol (40 mg/ml)
性状:Yellow waxy solid
存储:-20°C
Activity (short version):JMJ H3K27 Demethylase inhibitor (Cell Permeable)
Function / Pharmacology:Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.
