纯度:98% by TLC,;NMR (Conforms)
分子式:C15H16ClN5
分子量:301.78
溶剂:DMSO (25 mg/ml) Ethanol (3 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Src family kinase inhibitor
Function / Pharmacology:Potent and selective Src family kinase inhibitor. Inhibits Lck(IC50=4 nM); Fyn (IC50=5 nM); Hck (IC50=5 nM). It displays weak inhibition of EGFR (IC50=480 nM) and no inhibition of ZAP-70 (IC50> 100 μM) and JAK2 (IC50> 50 μM)1. It is a useful probe for exploring the involvement of Src family kinases in signal transduction pathways2.