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KL-001
- 英文名称：KL-001
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10303
- cas：309928-48-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-10-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10303 |
| 用途 | 科研检测 |
| 英文名称 | KL-001 |
| 包装规格 | 1MG |
| CAS编号 | 309928-48-1 |
| 别名 | KL-001 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C21H22N2O4S
分子量:398.46
溶剂:DMSO (100 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:RT
Activity (short version):Cryptochrome (CRY) activator
Function / Pharmacology:A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes1. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure2. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.
分子式:C21H22N2O4S
分子量:398.46
溶剂:DMSO (100 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:RT
Activity (short version):Cryptochrome (CRY) activator
Function / Pharmacology:A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes1. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure2. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.
