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ML239
- 英文名称:ML239
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10307
- cas:1378872-36-6
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10307 |
用途 | 科研检测 |
英文名称 | ML239 |
包装规格 | 1MG |
CAS编号 | 1378872-36-6 |
别名 | ML239 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C13 H10 Cl3 N3 O2
分子量:346.60
溶剂:DMSO (25 mg/ml) DMF (25 mg/ml) Ethanol (25 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Selective cancer stem cell killer
Function / Pharmacology:A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3
分子式:C13 H10 Cl3 N3 O2
分子量:346.60
溶剂:DMSO (25 mg/ml) DMF (25 mg/ml) Ethanol (25 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Selective cancer stem cell killer
Function / Pharmacology:A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3