纯度:98% by TLC,;NMR (Conforms)
分子式:C13 H10 Cl3 N3 O2
分子量:346.60
溶剂:DMSO (25 mg/ml) DMF (25 mg/ml) Ethanol (25 mg/ml)
性状:Beige solid
存储:-20°C
Activity (short version):Selective cancer stem cell killer
Function / Pharmacology:A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3