纯度:>98% by TLC,;NMR (Conforms)
分子式:C23H17N3OS3
分子量:447.59
溶剂:DMSO (40 mg/ml with warming)
性状:Off-white solid
存储:-20°C
Activity (short version):OXE-R biased antagonist
Function / Pharmacology:Gue1654 is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid2. It selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R.1,3 Gue1654 alleviated coronary artery ligation-induced ischemic myocardial injury in a mouse model.4