纯度:98% by TLC,;NMR (Conforms)
分子式:C13H11ClN2O5S2
分子量:374.81
溶剂:DMSO (60 mg/ml) Ethanol (5 mg/ml with warming)
性状:White solid
存储:-20°C
Activity (short version):RGS4 inhibitor
Function / Pharmacology:CCG-4986 is the first selective non-peptide inhibitor of the regulator of G protein signaling protein subtype RGS4.1 It covalently2-3 modifies RGS4 by inhibiting its interaction with Gα (IC50 = 3-5 mM) and suppressing GTPase activity1. Intratympanic administration of CCG-4986 was shown to rescue cochlear injury and hearing loss induced by acoustic overexposure and represents a novel paradigm for the treatment of sensorineural hearing loss via pharmacological regulation of GPCR signaling.4 A novel tool for exploring the involvement of RGS4 in physiological processes.5