纯度:98%,;NMR (Conforms)
分子式:C16H14N2O4
分子量:298.29
溶剂:DMSO (60 mg/ml)
性状:White solid
存储:RT
Activity (short version):TBK1 inhibitor / Antidiabetic
Function / Pharmacology:Improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1 (TBK1) and IKK? (IC50=1.2 ?M).2 Clinically useful in the treatment of aphthus ulcers.3 Inhibits prostate tumor metastasis by targeting IKK?/TBK1/NF?B signaling.4