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ML-SA1
- 英文名称:ML-SA1
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10325
- cas:332382-54-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10325 |
用途 | 科研检测 |
英文名称 | ML-SA1 |
包装规格 | 1MG |
CAS编号 | 332382-54-4 |
别名 | ML-SA1 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C22H22N2O3
分子量:362.43
溶剂:DMSO (20 mg/ml) Ethanol (10 mg/ml)
性状:Tan solid
存储:RT
Activity (short version):TRPML activator
Function / Pharmacology:TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4
分子式:C22H22N2O3
分子量:362.43
溶剂:DMSO (20 mg/ml) Ethanol (10 mg/ml)
性状:Tan solid
存储:RT
Activity (short version):TRPML activator
Function / Pharmacology:TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4