纯度:98% by TLC (5% CH3OH in CH2Cl2 Rf=0.34)
分子式:C22H26N3O2S
分子量:396.53
溶剂:DMSO (50 mg/ml) Ethanol (25 mg/ml)
性状:White solid
存储:RT
Activity (short version):TRPC3/6 activator
Function / Pharmacology:TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 μM and 0.44 μM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1μM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1μM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2