纯度:>98% by TLC;NMR (Conforms)
分子式:C22H30O2S
分子量:358.54
溶剂:DMSO (20 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:RT
Activity (short version):Ras inhibitor
Function / Pharmacology:Salirasib is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3. It has been investigated in the treatment of various cancers.4,5 HCC cells pretreated with salirasib were sensitized to TRAIL-induced apoptosis.6 Salirasib has also been shown to inhibit TRPA1 (EC50 = 1.3 μM).7