纯度:>98% by TLC;NMR (Conforms)
分子式:C20H19BrN4O3
分子量:443.30
溶剂:DMSO (25 mg/ml)
性状:Tan to yellow solid
存储:-20°C
Activity (short version):Survivin inhibitor
Function / Pharmacology:A novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1 Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2 Induces DNA damage.3 Induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4