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PRT4165
- 英文名称:PRT4165
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10357
- cas:31083-55-3
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10357 |
用途 | 科研检测 |
英文名称 | PRT4165 |
包装规格 | 1MG |
CAS编号 | 31083-55-3 |
别名 | PRT4165 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C15H9NO2
分子量:235.24
溶剂:DMSO (25 mg/ml) Ethanol (6 mg/ml)
性状:Yellow solid
存储:RT
Activity (short version):E3 ubiquitin ligase inhibitor
Function / Pharmacology:Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2
分子式:C15H9NO2
分子量:235.24
溶剂:DMSO (25 mg/ml) Ethanol (6 mg/ml)
性状:Yellow solid
存储:RT
Activity (short version):E3 ubiquitin ligase inhibitor
Function / Pharmacology:Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2