纯度:98% by TLC,;NMR (Conforms)
分子式:C15H9NO2
分子量:235.24
溶剂:DMSO (25 mg/ml) Ethanol (6 mg/ml)
性状:Yellow solid
存储:RT
Activity (short version):E3 ubiquitin ligase inhibitor
Function / Pharmacology:Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2