纯度:98% by TLC,;NMR (Conforms)
分子式:C19H15Cl2N3O2S2
分子量:452.38
溶剂:DMSO (35 mg/ml) Ethanol (5 mg/ml)
性状:Off-white solid
存储:RT
Activity (short version):RNA Polymerase III inhibitor
Function / Pharmacology:A broad spectrum inhibitor of RNA polymerase III from S. Cerevisiae as well as from human cells, IC50=32 μM and 27 μM respectively.1 Combined treatment with ML60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2