纯度:98% by TLC,;NMR (Conforms)
分子式:C27H28N2O3
分子量:428.54
溶剂:DMSO (40 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:RT
Activity (short version):Adiponection agonist
Function / Pharmacology:A novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively1. Displayed similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reversed insulin resistance and glucose intolerance in mice on a high-fat diet. It ameliorated diabetes in a genetically obese mouse model and prolonged the shortened lifespan of db/db mice on a high-fat diet1. Active in vivo.