纯度:98% by TLC,;NMR (Conforms)
分子式:C26H31Cl2N3 · 3(H3PO4)
分子量:750.45
溶剂:DMSO (25 mg/ml)
性状:Light brown solid
存储:RT
Activity (short version):GFRα1 agonist
Function / Pharmacology:A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson’s disease therapeutics.4