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XIB4035
- 英文名称:XIB4035
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10365
- cas:10023-54-8
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10365 |
用途 | 科研检测 |
英文名称 | XIB4035 |
包装规格 | 1MG |
CAS编号 | 10023-54-8 |
别名 | XIB4035 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C26H31Cl2N3 · 3(H3PO4)
分子量:750.45
溶剂:DMSO (25 mg/ml)
性状:Light brown solid
存储:RT
Activity (short version):GFRα1 agonist
Function / Pharmacology:A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson’s disease therapeutics.4
分子式:C26H31Cl2N3 · 3(H3PO4)
分子量:750.45
溶剂:DMSO (25 mg/ml)
性状:Light brown solid
存储:RT
Activity (short version):GFRα1 agonist
Function / Pharmacology:A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson’s disease therapeutics.4