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GPI-16552
- 英文名称：GPI-16552
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10376
- cas：443794-40-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-07-16
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10376 |
| 用途 | 科研检测 |
| 英文名称 | GPI-16552 |
| 包装规格 | 1MG |
| CAS编号 | 443794-40-9 |
| 别名 | GPI-16552 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C33H30N2O3
分子量:502.62
溶剂:DMSO (25 mg/ml) DMF (25 mg/ml)
性状:Pale yellow solid
存储:RT
Activity (short version):PARG inhibitor
Function / Pharmacology:A novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM1. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia2. It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model3 and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma4. Synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells5.
分子式:C33H30N2O3
分子量:502.62
溶剂:DMSO (25 mg/ml) DMF (25 mg/ml)
性状:Pale yellow solid
存储:RT
Activity (short version):PARG inhibitor
Function / Pharmacology:A novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM1. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia2. It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model3 and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma4. Synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells5.
