纯度:98% by TLC,;NMR (Conforms)
分子式:C25H30N2O5
分子量:438.52
溶剂:DMSO (50 mg/ml) Ethanol (10 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Notch pathway inhibitor
Function / Pharmacology:FLI-06 was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER and is thus a novel agent acting at an early stage in secretory traffic (EC50=2.3 ?M).1 Abolishes MFAP5-dependent transcriptional programs which are upregulated in intrahepatic cholangiocarcinoma.2 Suppresses proliferation and induces apoptosis in esophogeal squamous cell carcinoma cells.3