纯度:98% by TLC,;NMR (Conforms)
分子式:C15H11NO3S2
分子量:317.39
溶剂:DMSO (30 mg/ml)
性状:yellow solid
存储:RT
Activity (short version):IRE1 ribonuclease inhibitor
Function / Pharmacology:A novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress1-3. It displays significant antimyeloma activity in model human MM xenografts1. Induces apoptosis in pancreatic cancer cells and displays growth inhibition in a clonogenic growth assay in soft agar as well as in a xenograft in vivo model of pancreatic cancer4. Active in vivo.