纯度:98% by TLC,;NMR (Conforms)
分子式:C21H17NO3S2
分子量:395.50
溶剂:DMSO (40 mg/ml) Ethanol (20 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):ATM Kinase inhibitor
Function / Pharmacology:Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro.2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3 Sensitizes radio-resistant cancer cells.4 Provides neuroprotection against H2O2-induced cell damage.5