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KU-55933
- 英文名称:KU-55933
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10389
- cas:587871-26-9
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10389 |
用途 | 科研检测 |
英文名称 | KU-55933 |
包装规格 | 1MG |
CAS编号 | 587871-26-9 |
别名 | KU-55933 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C21H17NO3S2
分子量:395.50
溶剂:DMSO (40 mg/ml) Ethanol (20 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):ATM Kinase inhibitor
Function / Pharmacology:Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro.2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3 Sensitizes radio-resistant cancer cells.4 Provides neuroprotection against H2O2-induced cell damage.5
分子式:C21H17NO3S2
分子量:395.50
溶剂:DMSO (40 mg/ml) Ethanol (20 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):ATM Kinase inhibitor
Function / Pharmacology:Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro.2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3 Sensitizes radio-resistant cancer cells.4 Provides neuroprotection against H2O2-induced cell damage.5